Category Archives: Government/Research

Federal Funding Advances “Holy Grail” of TBI Diagnosis

A Boston company developing a non-invasive way to detect dangerous brain swelling after traumatic brain injury has received $5.5 million in federal funding from the NIH Blueprint MedTech Program and Department of War’s Joint Warfighter Medical Research Program.

This new non-invasive technology, CranioSense, uses a forehead patch and clip-on sensors to detect elevated pressure without surgery and could transform TBI emergency care. Currently, measuring intracranial pressure – which if elevated can cause brain damage, coma, or death – requires drilling into the skull. This limits testing of brain swelling to only the most critical patients, meaning only approximately 2% of TBI patients ever have their brain pressure measured.

A retired U.S. Army Special Operations Command consultant called the new technology “a ‘Holy Grail’ of prolonged casualty care” that addresses “one of the biggest gaps in monitoring critical casualties.”

The December 2025 grants will support device development and validation ahead of FDA approval. If cleared, the system could make brain pressure assessment “as routine as blood pressure measurement” in emergency rooms, on battlefields, and at accident scenes – catching dangerous swelling early when intervention can save lives.

Should 2026 Fiscal Year Funding Concern the Brain Injured?

President Trump signed S.1071 into law on December 18, 2025. The National Defense Authorization Act for Fiscal Year 2026 was sponsored by Sen. John Cornyn (TX), and co-sponsored by Sen. Ted Cruz (TX), and received bipartisan support in Congress. The House passed the measure 312-112 on December 10, with the Senate approving it 77-20 one week later.

Similar to the redesignation of the Department of Defense as the Department of War, the $900 billion defense package appears to focus more on military action than research  As early as May 2025, ESPN reported, “The Trump administration’s 2026 fiscal budget request to Congress eliminates major federal funding for traumatic brain injury (TBI) research and education, potentially undercutting efforts to address head injuries in sports, particularly at the high school and youth levels.” The 2024 funding bill also included decreased funding for brain injury research. 

Whether the bill affects treatment options and research, and to what level, is to be seen.* It appears that some broader funding can be given to any study, even if it goes above the mandated TBI research amount. Additionally, most of the plentiful research I report on seems to be unrelated to the Department of War.

*Only one day prior to the signing of S.1071, Rep. Lori Trahan (MA) introduced H.R.6823 – “To direct the Secretary of Defense to establish a pilot program to facilitate the development of certain traumatic brain injury diagnostics for members of the Armed Forces.” On that day, December 17, 2025, it was referred to the House Committee on Armed Services. Since that time, no further action has been taken.

Molecular Drug Carrier Turns Out To Be Drug Itself

A four-amino-acid peptide called CAQK (Cysteine-Alanine-Glutamine-Lysine) has emerged as a promising therapeutic candidate for traumatic brain injury. This artificially produced peptide was first discovered in 2016 by researchers at Sanford Burnham Prebys Medical Discovery Institute (CA) – it’s like a delivery drone that scientists built to recognize those specific warning signs and go directly to them

Since that time, the National Institutes of Health has continued to support CAQK research through multiple grants, such as a 2025 $2.5 million SBIR award to AivoCode, the biotech company developing CAQK for clinical trials. A resulting 2025 study published in EMBO Molecular Medicine revealed that CAQK possesses intrinsic neuroprotective properties – reducing lesion size, decreasing cell death, and alleviating neuroinflammation in mice with brain injuries. This discovery transforms CAQK from merely a drug delivery vehicle into a potential standalone treatment – a significant advancement in neuroscience research.

Challenges of the Cold Zone   

Whether you call it spacing out, daydreaming, or mind wandering, zoning out reportedly occupies roughly 40% of our daily mental activity. Winter months may make it worse – a 2021 NIH systematic review found that 15 of 18 studies showed cold exposure impairs cognitive performance, particularly attention and processing speed. Neuroimaging research also reveals that brain responses for sustained attention reach their minimum around the winter solstice.

The holiday season poses additional challenges. Studies show 64% of mind wandering is future-oriented, with 44% devoted to planning daily obligations. For children – who are already off-task about 24% of the time, according to 2024 NIH research – anticipating holiday events and presents can overwhelm developing executive function, leading to inattention and emotional outbursts. Adults juggling parties, gift-giving, and travel face similar struggles.

This inattention can carry serious consequences. Zoning out while driving can result in driving activity, or inactivity, that may lead to accidents that negatively affect the driver and others; distracted driving alone killed 3,275 people in 2023, while an estimated 325,000 people were injured that same year – the specific number of traumatic brain injuries that resulted from these accidents is unknown. But NIH-published studies report that the relationship, of course, works both ways, as brain injuries damage frontal lobes essential for focus.

Government health agencies recommend combating attention lapses year-round through adequate sleep of about 7-9 hours nightly, taking short breaks during demanding tasks, breaking large projects into smaller steps, and practicing mindfulness techniques that gently redirect wandering thoughts rather than suppressing them. For brain injury survivors, the recommendations for coping with the winter, in general, and the winter holiday season are much the same: prioritize rest, simplify holiday activities, maintain routines, reduce sensory overstimulation, and practice metacognitive strategies by planning ahead and recognizing limits.

Genetic “Light Switch” Could Turn Off Pediatric Brain Injury

“Epigenetics refers to how your behaviors and environment can cause changes that affect the way your genes work,” reports the CDC. As defined by the NIH National Cancer Institute, a methyl group is, “a small molecule made of one carbon and three hydrogen atoms.” Epigenetic changes can include DNA methylation: this addition of the methyl group to cytosine. (Cytosine is, “chemical compound that is used to make one of the building blocks of DNA and RNA,” notes the NCI.) These modifications, that turn genes “on” or “off” without altering DNA itself, act as a cranial “light switch”, as they, “encode a member of the nerve growth factor family of proteins… promoting binding of this protein to its cognate receptor promotes neuronal survival in the adult brain.”

It may be difficult to fully understand how the aforementioned scientific information relates directly to brain injury, but recent study results further lay out the benefits of DNA methylation in recovery. In December 2025, University of Pittsburgh researchers published findings in the Journal of Neurotrauma related to epigenetics and brain injury. Led by Dr. Lacey Heinsberg and Dr. Amery Treble-Barna, the study examined nearly 300 children at UPMC Children’s Hospital, discovering that children with traumatic brain injuries showed significantly lower DNA methylation of the BDNF gene (Brain-Derived Neurotrophic Factor) compared to children with orthopedic injuries. 

Encouragingly, these negative changes appear reversible. “DNA methylation is dynamic and modifiable, which means it could respond to interventions like diet, exercise and therapy,” Dr. Heinsberg noted. These findings open doors for personalized rehabilitation strategies that could actively improve recovery for children with brain injuries.

Phantom Brain Emerges from NRL/VCU Collaboration

“The word ‘phantom’ may conjure up scary ideas, like ghosts, delusions or fake bank accounts… [but] medical imaging phantoms are objects used as stand-ins for human tissues,” according to the National Institute of Standards and Technology of the U.S. Department of Commerce. “Phantoms offer… comprehensive assessments and iterative optimization of imaging modalities… enabling improvements in their chances of success before human studies,” reported the NIH in May 2024.

Announced December 8, 2025, scientists at the U.S. Naval Research Laboratory in Washington D.C. and Virginia Commonwealth University in Richmond have developed the first anatomically accurate rat brain phantom capable of measuring traumatic brain injury impacts in real time. This breakthrough emerged from a multi-year partnership between NRL physicist Dr. Margo Staruch and VCU professor Dr. Ravi Hadimani.

The phantom uses a custom gel-like material that mimics real brain tissue’s consistency.  Working like a tiny power generator activated by pressure, an embedded sensor converts physical impacts into measurable electrical signals. It replicates the brain’s distinct layers: skull, cerebrospinal fluid (the protective liquid cushioning the brain), gray matter, and white matter.

“That information can directly inform the design of improved helmets and protective gear, leading to better protection for warfighters and will also contribute to better diagnostic and treatment pathways for TBI,” said Staruch.

Give Your Brain a Gift: Benefit of Creative Activities in Brain Injury Recovery and Beyond

Creative hobbies strengthen brain health in everyone, but they hold particular promise for those recovering from brain injury. Activities like painting, dancing, music, creative writing, pottery, and even certain video games engage multiple brain regions, enhancing memory, coordination, and emotional well-being.

A 2025 study published in Nature Communications, and found in the NIH dababase, examined brain data from over 1,400 participants across 13 countries and found that creative activities can slow brain aging and promote healthier brain function. Lead researcher Dr. Carlos Coronel noted that “these creative experiences help protect brain connections that are vulnerable to accelerated aging.”

Related to brain injury survivors specifically, creative arts therapies show measurable benefits. As President Franklin D. Roosevelt, who suffered significant neurological issues and found solace in creative hobbies during his recovery from polio, declared: “I owe my life to my hobbies.” 2025 research reports in the Archives of Physical Medicine and Rehabilitation, in the NLM database, note that there is increasing use of creative arts therapy for addressing traumatic brain injury, from intensive care units to home health. Studies demonstrate positive impacts on daily living activities, motor function, and emotional well-being. In fact, the neurological changes following brain injury may actually enhance artistic capabilities through increased neural plasticity and synapse formation.

Crucially, these benefits extend beyond formal rehabilitation. Continuing creative pursuits long-term helps maintain neural connections in everyone, making it essential for survivors to keep practicing their creative hobbies. The holiday season offers perfect opportunities – crafting decorations, creating handmade gifts, baking festive treats, and arranging seasonal displays all provide therapeutic engagement.

Congressional Visit Highlights CU COMBAT Center’s Great Work

Rep. Jeff Crank (CO, 5th District) recently toured the CU Anschutz Center for COMBAT Research, the nation’s largest academic military health research program. Crank, who serves on the House Armed Services Committee and who’s district is home to five military installations, the United States Air Force Academy and a large veteran population, praised the center’s “great work” saving servicemembers’ lives. (Previously, Crank co-sponsored the bipartisan SMART for TBI Act with Rep. Jason Crow, requiring the military to develop AI-driven traumatic brain injury treatments.)

The COMBAT Center, focused on blast-related injuries, including brain injury, has robust government engagement through over 80 Department of War-funded research grants and educational partnerships with the Defense Health Agency, Uniformed Services University, and the U.S. Air Force Academy. These collaborations have updated 13 military clinical practice guidelines and modernized training for thousands of combat medics.

This partnership between congressional leadership and academic research continues advancing innovative solutions that benefit both military and civilian communities.

Teletherapy Promising for TBI Emotional Recovery

A major government-funded initiative is further advancing the understanding of teletherapy for emotional health challenges following traumatic brain injury. In December 2025, the U.S. Department of War announced a $4.3 million multi-site study testing Building Emotional Self-Awareness Teletherapy (BEST), led by the Hackensack Meridian JFK Johnson Rehabilitation Institute (NJ) and designed to help brain injury survivors recognize and regulate emotions.

The DoW’s Congressionally Directed Medical Research Programs is funding this nationwide study through its Traumatic Brain Injury and Psychological Health Research Program with partner institutions, including the Indiana University School of Medicine, the National Intrepid Center of Excellence, and the University of South Florida. The study will enroll 152 civilian and military participants experiencing emotional dysregulation after mild traumatic brain injury.

The federal government’s exploration into telehealth, in relation to brain injury, has long been studied. As early as 2003, the NIH reported that, “A case study is presented in which teletherapy was successfully utilized to improve the functional outcomes, both physical and cognitive, of a patient with a severe TBI.” More recent government-supported research, led by the University of Washington and UC San Diego and published in July 2025 in Frontiers in Neurology found that telehealth interventions significantly improved depression, anxiety, PTSD, and sleep symptoms in service members with concussions.

Preliminary results are encouraging: 83% of BEST participants reported noticeable improvement in functioning. These developments offer hope that accessible remote therapy can transform emotional recovery for millions affected by brain injury.

Holiday Season’s Favorite Flavor Could Help Brain Injury Recovery

The aroma of candy canes dangling from Christmas trees, the rich sweetness of peppermint bark shared among friends, the warming comfort of peppermint hot chocolate on a cold night, mint is a staple of winter season. Throughout the years, scientists involved in various studies have found that the benefits of mint go beyond taste.

Menthol, mint’s active compound, can be thought of as a targeted healing agent. Millenia ago, Aretaeus of Cappadocia, a physician in the 2nd century AD in Ancient Greece, first documented mint’s effects on the nervous system when he recommended it to treat epilepsy, a possible side effect of brain injury. A 2022 study in the Journal of Neuroinflammation showed it reduced stroke damage and accelerated recovery. How? By calming inflammation in injured brain tissue, ramping up the body’s natural antioxidant defenses, and improving blood flow to areas desperately needing oxygen and nutrients – the trifecta of post-injury healing.

Studies found in the NIH database confirm that mint doesn’t just freshen breath, it strengthens the brain. A 2018 trial discovered that spearmint extract improved working memory by 15%, while 2008 research revealed that simply smelling peppermint enhanced memory and alertness.

Most exciting? A groundbreaking May 2025 study from Northumbria University found that drinking just one cup of peppermint tea significantly boosted memory, attention, and working memory in healthy adults, with effects appearing within mere minutes. “Those people who had drunk the peppermint tea had better long-term memory,” explains Dr. Mark Moss of Northumbria University, whose research appears in NIH databases. That simple cup of tea may do more for your brain than you ever imagined.

While mint may be a star in the winter, you don’t have to limit consumption of the mint to December. Summer brings mojitos and mint juleps mocktails. Mediterranean kitchens toss mint into tabbouleh salad and swirl it into creamy tzatziki. And, of course, fresh mint ice cream is always a tasty dessert. From ancient remedy to modern superfood, this versatile herb truly deserves a spot at your table year-round.