
For years, fish oil has been championed as a go-to supplement for brain health, with athletes, military veterans, and concussion patients reaching for it as a matter of routine. But a landmark 2026 study by researchers at the Medical University of South Carolina, Cold Spring Harbor Laboratory, and Boston University is casting serious doubt on that assumption.
The issue is EPA, which is one of the two major omega-3 fatty acids in most fish oil supplements. Researchers found that EPA may disrupt the brain’s natural blood-vessel repair process after repeated head injuries, and elevated EPA levels were also detected in postmortem CTE brain tissue. Crucially, DHA, the other primary omega-3, showed no such harmful effect.
Adding to the concern are the results of a separate 2026 study using the Alzheimer’s Disease Neuroimaging Initiative. This cohort independently linked omega-3 supplement use to faster cognitive decline in older adults.
Researchers are careful to stress these findings don’t make fish oil universally dangerous. The message, however, is clear: for anyone with a history of head trauma, a conversation with your doctor is now essential before continuing supplementation.










