Tag Archives: infant

Pregnant Brain’s Resilience Comes With Risk

Diagram showing pregnant woman with brain regions labeled for hormone regulation, emotional processing, memory, planning, and neural plasticity, plus uterus and fetus.

As any person who has given birth will confirm, pregnancy transforms nearly every system in the body. The brain is no exception to this change. Much of this neurological alteration is remarkably positive, but, as with other major body occurrences, some of it is genuinely alarming.

Estrogen and progesterone, which surges throughout pregnancy, are now being studied as neuroprotective and neuroregenerative agents in strokes and other brain injuries. Research shows these hormones can reduce the injury cascade by enhancing antioxidant mechanisms, reduce excitotoxicity, and stimulate remyelination. As researchers put it: “Estrogen seems more effective as a prophylactic treatment in females at risk for ischemic brain injury, whereas progesterone appears more helpful in post-injury treatment of both male and female subjects with acute traumatic brain damage.” Additionally, the 2022 Rotterdam Study, available on PubMed, examined 2,835 women over decades, finding that pregnancy and childbirth are associated with a robustly larger global gray matter volume that persists for decades.

The story, though, isn’t all rosy. More recently, contradictory study results have been found. 2025 MRI research published in the International Journal of Molecular Sciences, found on PubMed, showed that pregnancy reduces total cortical gray matter volume by an average of 3%, with losses concentrated in regions linked to social cognition and self-awareness. More acutely, an estimated 7.7 – 15% of all maternal deaths worldwide are caused by stroke, and 30 – 50% of surviving women are left with persistent neurological deficits. “Female stroke survivors were more than twice as likely as their stroke-free counterparts to have another stroke while pregnant and in the six weeks after childbirth,” reported the 2026 American Stroke Association International Stroke Conference.

Ultimately, the pregnant brain endures, often emerging stronger. But, as with every activity that has a significant effect on the body’s function, proper monitoring is required, with even more caution needed for those with a history of brain injury.

“Marty Supreme” Brings Attention to Ping Pong’s Dual Role in Brain Health

As many anticipate 2026 Academy Award nominations to be announced tomorrow, one film, in particular, has gained Oscar buzz for cinematic acumen and, from me, its focus on an often overlooked sport. An A24 Films production Marty Supreme follows a 1950s ping pong hustler through his rise to glory. (Timothée Chalamet, who portrays the star table tennis player, has already won a Golden Globe for the role.) But beyond Hollywood, the sport at the heart of the film has proven transformative for brain injury patients.

Recent NIH research reveals that ping pong has remarkable therapeutic potential for traumatic brain injury recovery. A 2024 study published in Brain Research and indexed in NIH PubMed demonstrated that long-term table tennis training significantly alters dynamic functional connectivity and white matter microstructure in large-scale brain regions – enhancing cognitive function and attention in patients recovering from neurological injuries. This is due to the sport’s simultaneous engagement of visual tracking, motor coordination, and rapid decision-making, which triggers neuroplasticity, the brain’s ability to rewire itself. A 2024 stroke rehabilitation study in the database showed significant brainwave changes in patients practicing seated table tennis, with enhanced activity in frontal and temporal regions associated with sensorimotor integration. This additionally supports broader applications of the sport for traumatic brain injury rehabilitation.

However, the term “ping pong” isn’t singly used to define the sport of table tennis. Ironically, “ping pong fracture” is the term used to describe a very serious infant condition: a depressed skull fracture that resembles a dented ball. These fractures occur in approximately 3 per 10,000 live births, often as the result of difficult deliveries. Fortunately, a 2022 World Neurosurgery systematic review of 228 cases found 96.4% achieve favorable outcomes without lasting neurological damage. Most resolve spontaneously within six months.

As is apparent, science continues to prove that ping pong’s medical connections, whether through the healing effects to the injured brain of gameplay or used to describe neonatal trauma, run deeper than any championship rally.

Two NIH-Funded Studies Offer Hope for Preventing Neonatal Brain Injury in 2026

As reported in the NIH database in November 2025, “In recent years, there has been increasing interest in identifying and validating biomarkers capable of predicting the onset and progression of IVH, as well as other forms of neonatal brain injury.“ Two studies published this month offer fresh hope for preventing and treating neonatal brain injuries, conditions that affect thousands of American infants each year and can lead to lifelong disabilities.

Detailed in Pediatric Research on January 3, a comprehensive care model demonstrates how integrated treatment from prenatal care through early childhood can improve outcomes for at-risk newborns. Of the approximately 3.6 million babies born annually in the United States, about 10 – 15% require Neonatal Intensive Care Unit admission. The collaborative program addresses what researchers call a critical window, as “injuries during these stages can lead to lifelong disabilities.”

Meanwhile, Stanford University researchers reported January 5 in the Journal of Perinatology that advanced monitoring techniques can better predict dangerous brain bleeds in premature infants. Their study of 482 preterm babies found that low cerebral oxygenation increases mortality risk more than fourfold.

Both studies build upon past NIH-supported research through the Neonatal Research Network.