Tag Archives: JAMA Neurology

Widely Used Birth Control Comes With Brain-shaped Asterisk

Vial of Depo-Provera and syringe on medical tray

Per the CDC, roughly 1 in 4 sexually active American women have used the form of birth control Depo-Provera. Studies, though, found that the effects of this injectable go beyond contraception. The government paper trail also keeps growing, regarding the risks it may cause.  A JAMA Neurology study found a 2.43-fold higher risk for developing a brain tumor among users. Just this month, on July 2, 2026, another JAMA study flagged the injection as having the strongest risk of brain tumor development of any contraceptive. (This study also reported reassuring news: risk fades within roughly five years of stopping. Additionally, absolute risk stays low, as less than 5 in 10,000 women have this extremely negative effect.)

According to the Mayo Clinic, “Depo-Provera is a birth control shot that has the hormone progestin.” In actuality, it injects medroxyprogesterone acetate, a synthetic version of the natural hormone progesterone.  Long-term use of this injection can result in meningiomas, which are usually benign brain tumors. Meningiomas, though, can crowd the brain, triggering headaches, vision loss, and seizures. In December 2025, the U.S. Food and Drug Administration ordered a warning on the Depo-Provera label.

Meanwhile, Pfizer reached a June 2026 settlement covering over 5,500 federal lawsuits alleging it downplayed the danger. Though this number may seem large, the percent of Depo-Provera users it represents is small. So, users shouldn’t panic but should talk to their doctor about duration of use.

Tackles and Trauma: As Rugby Booms in U.S., Brain Science Sounds the Alarm

Major League Rugby logo with player running holding rugby ball

This past weekend’s Major League Rugby Championship underscored rugby’s arrival in Illinois. With over 50,000 youth registrations in 2024 and more than 370,000 children introduced to the sport through outreach programs in 21 states, the game is one of the fastest-growing youth sports in the country.

For those who have already sustained a brain injury, structured aerobic activity, like the non-contact formats of tag and flag rugby, offer genuine therapeutic benefit. The sport’s emphasis on teamwork and communication also supports psychosocial recovery, reducing isolation among those navigating long-term concussion symptoms.

Irish rugby player O'Sullivan holding ball and scoring while tackled by a Scottish player in muddy conditions

Yet the neuroscience demands caution. A 2023 study in Acta Neuropathologica found CTE in 68% of donated former-rugby brains, with risk rising 14% per additional year of play. A 2023 NIH-backed study in JAMA Neurology found CTE in 41% of contact-sport athletes under 30. The CDC estimates up to 3.8 million sports concussions annually. Sen. Maggie Hassan (NH) has called for action, stating that “the full scope of these injuries often goes unrecognized.”