Texas First to Fund New Psychedelic Research

Texas has made history by becoming the first state to allocate significant public funding for psychedelic medicine research. Governor Greg Abbott signed Senate Bill 2308 into law in June 2025, committing $50 million to FDA-approved clinical trials of ibogaine, a psychedelic compound derived from an African shrub.

The groundbreaking legislation represents the largest government investment in psychedelic research to date, positioning Texas as a global leader in this emerging field. The initiative aims to develop FDA-approved treatments for opioid addiction, traumatic brain injury (TBI), and PTSD—conditions that have devastated countless lives across America.

Rick Perry’s Pivotal Role

Former Texas Governor Rick Perry has emerged as an unlikely but passionate advocate for ibogaine research. His involvement began through his relationship with Navy SEAL veterans Marcus and Morgan Luttrell, who found relief from combat-related trauma through ibogaine treatment in Mexico. After witnessing their remarkable recoveries, Perry dedicated himself to advancing this cause, even launching the nonprofit Americans for Ibogaine.

“I’ve spent most of my adult life in public service, and few things have moved me like what I’ve witnessed with this psychedelic drug,” Perry wrote in a recent op-ed, describing how ibogaine helped veterans overcome years of opioid dependence and psychological trauma.

Promising Results for Brain Injury

Recent Stanford Medicine research found that ibogaine, when combined with magnesium for heart protection, safely reduced PTSD symptoms by 88%, depression by 87%, and anxiety by 81% in combat veterans with traumatic brain injuries. The treatment appears to promote neuroplasticity, potentially helping the brain repair itself after injury.

While primarily focused on veterans, the research could benefit anyone suffering from brain trauma, including athletes with concussion-related injuries and accident victims. Texas’s historic investment may lead the way to finally bringing this promising treatment to American patients who have long traveled abroad seeking relief.

Texas SB 2308: https://capitol.texas.gov/BillLookup/History.aspx?LegSess=89R&Bill=SB2308

Government’s Critical Role in Toxic Exposure Crisis

Burn pits are massive open-air waste disposal sites used extensively by the military in combat zones. Specifically, from 2001 to 2011 in Iraq and Afghanistan, these giant outdoor incinerators were used to burn everything from plastics and medical waste to chemicals, batteries, ammunition, and office equipment, which resulted in the release of dangerous cocktails of carcinogens and toxic chemicals into the air that service members breathed daily. The Department of Defense estimates that 3.5 million troops were exposed to this toxic smoke during recent wars, making burn pit exposure one of the most widespread environmental hazards faced by military personnel.

While outcomes to exposure to these burn pits involving respiratory and cancer risks have previously been exposed, groundbreaking research released in July 2025 has revealed alarming long-term neurological consequences. A study of 440,000 veterans, conducted by the National Institutes of Health, Department of Defense, and Department of Veterans Affairs found that troops exposed to burn pit smoke had dramatically higher rates of brain injuries and psychological trauma. Veterans who lived near burn pits for at least 129 days were 27% more likely to experience severe stress symptoms and 37% more likely to suffer brain injuries compared to those at cleaner bases. Those with extended exposure of over 474 days showed 68% higher rates of severe stress and 124% increased likelihood of brain damage. More so, 90% of troops who died by suicide had served at bases with large burn pits for extended periods. The reason for these increases and terrible results appears to be exposure to toxic chemicals which disrupt brain function and neurotransmitters.

The military has responded with comprehensive reform measures. The Department of Defense has closed most burn pits and plans to eliminate all remaining sites. The 2022 PACT Act expanded healthcare and disability benefits for millions of veterans exposed to toxic environments, while 2025 H.R. 1, One Big Beautiful Bill Act, allocates $2 billion to defense health programs. These efforts represent crucial progress toward comprehensive care for veterans facing the invisible wounds of toxic exposure.

Government Moves Regeneration to the FRONT

The Advanced Research Projects Agency for Health (ARPA-H) has unveiled its transformative Functional Repair of Neocortical Tissue (FRONT) program, a bold five-year initiative aimed at developing curative therapies for millions of Americans suffering from chronic brain damage. This groundbreaking program positions the United States as the global leader in brain repair technology.

Under the current leadership in Washington, FRONT addresses one of America’s most pressing health challenges. HHS Deputy Secretary Jim O’Neill emphasized the program’s potential to “deploy regenerative medicine to transform the treatment of neurological diseases and relieve the suffering” of millions affected by strokes and traumatic brain injuries.

The program targets the neocortex, the brain’s largest region responsible for sensory perception, motor control, and higher cognitive functions. Currently, damage from stroke, trauma, or neurodegeneration leaves patients dependent on costly, limited therapies. FRONT aims to revolutionize treatment by using cutting-edge stem cell technology to regenerate brain tissue and restore lost functions.

“This will enable millions of individuals with what is currently considered permanent brain damage to regain lost functions, such as motor control, vision, and speech,” said FRONT Program Manager Jean Hebert, Ph.D.

The economic impact is remarkable. Brain damage costs the U.S. healthcare system over a trillion dollars annually, while FRONT is projected to save approximately $800 billion annually and recover lost taxable income from affected individuals.

The program prioritizes veteran support, targeting traumatic brain injuries—a leading cause of military disability. FRONT will use exclusively adult-derived dedifferentiated stem cells, ensuring ethical development while maintaining scientific rigor.

ARPA-H is soliciting proposals through September 25, 2025, focusing on graft tissue generation and engraftment procedures. With strict performance metrics designed to prepare for human clinical trials, FRONT offers unprecedented hope to over 20 million Americans with chronic neocortical brain damage and their families.

(For more information, visit the FRONT program page: https://arpa-h.gov/explore-funding/programs/front)

MO Brings Oxygen into TBI Recovery

Missouri has demonstrated remarkable commitment to our veterans with the ratification of SB 664 on July 14, 2025.  The “Veterans Traumatic Brain Injury Treatment and Recovery Act,” was passed with overwhelming support of 33-0 in the Senate and 156-1 in the House. Governor Mike Kehoe signed this groundbreaking legislation on Monday, establishing a fund to reimburse HBOT facilities treating veterans with TBI or PTSD, recognizing the treatment’s potential to combat veteran suicide and opioid addiction. The initiative represents a projected investment exceeding $5 million annually, underscoring the state’s confidence in this therapeutic approach.

HBOT works by delivering 100% oxygen in pressurized chambers at 1.4-3 times normal atmospheric pressure, dramatically increasing oxygen delivery to damaged brain tissues. Advocates report that this treatment “stimulates brain wound healing and can reverse soft tissue and neurocognitive damage” without requiring invasive surgery or pharmaceutical interventions. Patients can “experience recovery of cognitive and neurological functioning” through this non-invasive approach.

Clinical research has yielded encouraging results across multiple studies. For moderate-to-severe TBI cases, several high-quality studies demonstrated statistically significant improvements in consciousness recovery compared to standard care alone. Research has consistently shown better Glasgow Outcome Scale scores and reduced mortality rates in HBOT treatment groups. A comprehensive 2016 review highlighted that “most successes occurred within hours after TBI,” emphasizing the importance of early intervention. Particularly compelling evidence comes from pediatric research, where a study of 56 children with severe TBI found that HBOT “significantly improved quality of life and reduced complications” compared to control groups. Additional research involving 56 patients showed “significant improvement in symptoms and increased brain activity” measurable through SPECT brain imaging.

The treatment maintains a generally acceptable safety profile, with most side effects being minor and temporary, including ear discomfort, headaches, and fatigue. Serious adverse events remain rare when HBOT is properly administered. This positive safety record, combined with growing clinical evidence and strong legislative support, has led some VA facilities to begin offering HBOT treatment to veterans, representing an important step toward broader acceptance of this promising therapeutic intervention.

Update: Carl-Gustaf Rifle

What kind of damage is that doing to soldiers in training and on the battlefields?”  Over five years ago, I reported this statement, pronounced by a member of the Congressional Brain Injury Task Force regarding the heavy weapon Carl-Gustaf rifle.  Before 2017, the federal government knew the risks of the weapon.  The Department of Defense even launched a five-year study to evaluate this risk.  I personally thought, based on later articles, that currently, there were laws preventing troops from using the Carl-Gustaf system.  However, “U.S. Troops Still Train on Weapons with Known Risk of Brain Injury,” headlined an article in the New York Times yesterday, November 26, 2023.  The article is a good reminder of the peril our troops face in war, not just from opponents, but in training and defending our country and allies across the world.

UArizona Visualizes New Detection & Treatment for TBI

The Excellence in Prehospital Injury Care (EPIC) project has led to University of Arizona (UArizona) and various affiliates across the State to research new and varying aspects of brain injury.  Looking at the EPIC website, I could find no study report after 2019, and before 2019, there also was a 6-year gap in studies.  However, regardless of the operation of the EPIC Project, it is a well-regarded research university.  To that end, the Department of Defense recently announced that it has provided millions of dollars in grants to UArizona for new research that will increase knowledge and, hopefully, provide better solutions to identify and treat brain injury.

The most intriguing study, at least for a layman like me, is that of a portable video game to detect brain injury for which the DoD provided $1.5 million in funding.  The project, Model Development and Translation of a Virtual Reality Military Operational Neuropsychological Assessment, or VRMONA, involves immersing oneself in a combat-related activity with the use of a VR headset and a hand sensor system.  While one plays the immersive game, data is collected about the player’s accuracy, response time, motor coordination and inhibition.  The goal is to ready its use for the military, though those connected to the study hope that it can be used in civilian life too, such as in sports, in the future.

Additionally, new treatments for brain injury are always sought after by the government.  The University of Arizona Health Sciences was awarded $3 million to study if peptide hormones are an effective treatment for brain injury.  In the four-year study, they will be investigating the efficacy of one specific peptide hormone, angiotensin 1-7, in the treatment of brain injury.  (The NIH has found that, “Peptide hormones play a prominent role in controlling energy homeostasis and metabolism.”)

Skiing Into a Head Injury

Gliding down a ski slope at 60 mph, taking a ramp that lifts you up in the air with a heavy board attached to your feet and just snow below, or racing against others while doing both.  These three activities are all part of the winter routine for individuals who enjoy the extreme sports of freestyle skiing, snowboarding or snowcross.  Extreme sports are, by definition, dangerous.  A Google search of snowboarding, for example, found two pages of articles related to snowboarding deaths and accidents this year alone.

First coming into existence either in the 1950s, 1960s or 1970s, depending on which source you reference, extreme sports tap into a person’s sense of adventure.  Head and neck injuries due to winter extreme sports are common, when compared to other sports, partly because, “many extreme sports take place in environments where medical care may not be readily available.”

Throughout the years, extreme sports have become more popular, perhaps as the opportunity for adventure and physical risk of everyday life goes down and mental stress goes up.  Head and neck injuries due to winter extreme sports have also significantly increased through the years.  There is a cost to these injuries, both emotionally for the individual and monetarily for both the individual and the government through evacuation costs, rehabilitation costs and community costs in the future.  This month, the government pays more attention to these risks, as well as the needed research, as January is National Winter Sports Traumatic Brain Injury Awareness Month.

Although finding new means to treat traumatic brain injury in extreme winter sports is very important, “prevention is the top priority”.  The Office of Disease Prevention and Health Promotion reminds people to always wear a helmet and to make sure to watch your surroundings by staying in the boundaries in ski slopes and watching for obstacles and hazards on your path.  Just as importantly, “make sure medical care is close.”  Additionally, Dr. Pickett of the National Intrepid Center of Excellence reminds people that, “It’s important to consider how weather conditions… increase the risk for these injuries.”  While equipment is now safer and access to medical care has improved, prevention should always come first.  If you enjoy the thrill of extreme winter sports, I hope you enjoy it this winter, but know and use all available information to make it safe.

Brain Injury Task Force Loses a Chair

This week, the 116th Congress was sworn in on Capitol Hill.  Unfortunately, that means that the Congressional Brain Injury Task Force lost one of its Chairs, Congressman Thomas Rooney (FL), who did not seek reelection.

Having served in the Army for 4 years in combat and 4 years in the reserve, Rooney accorded special attention to brain injury in the military on the Task Force.  This summer, it was reported, “House Approves Rooney-Requested Funding for Traumatic Brain Injuries.”  (Seen now on the website VoteSmart, this article is a repost first seen on the official Congressional website for Rooney, which is now defunct.)  The requested funding given was $125 million.

As a member of the House Appropriations Committee, Rooney dealt with the financing of government bills and other such actions.  (The House Ways and Means Committee is also focused on financial needs, a Committee that counts co-chair of the Brain Injury Task Force Congressman Pascrell as a member.)  Of this victory, Rooney stated, “The reality is our service members take great risks when they enlist to fight for our country. One of the biggest risks is TBIs, which can lead to severe mental health issues like depression and even suicide. These problems are serious and real and each dollar we spend towards research and treatment puts us one step closer to helping our military.”  (It is important to note that the VA conducts research that benefits all Americans, not simply those in the armed forces.)

Rooney is succeeded in Florida’s 17th District by former State Legislator Greg Steube.  Like his predecessor, Steube is a veteran with 4 years in combat.  Hopefully, Steube will have as much consideration for brain injury as his predecessor, too.

 

Link: Promoting better understanding, treatment of traumatic brain injury

Throughout the year, the armed forces have either started or continued to care for the thousands of injured soldiers who suffer from brain injury.  In addition, they have persevered in their research into various neurological issues related to TBI and new methods of treatment for TBI recovery.  Yesterday, the Military Health System Communications Office posted on their website a press release that serves as a synopsis of their activities throughout the year.  Beyond highlighting achievements, the release, titled Promoting better understanding, treatment of traumatic brain injury, also notes the need for further research and care.  On the webpage, below the press release, are links to articles that further explain the accomplishments mentioned.  (They particularly note the discovery of a blood test to detect brain injury, an accomplishment that was first reported on this website in March 2018.)

R.I.P. President George H.W. Bush

Today, at 11:00am ET, former Presidents, dignitaries, family members and others pay tribute to the 41st President of the Unites States, George H.W. Bush.  For the purpose of this website, it is a day to remember all that President Bush did for those with brain injuries, and for those with disabilities, at large.

President Bush was America’s last president to serve in the military overseas at war.  (President Clinton, President Obama and President Trump did not serve.  President George W. Bush served stateside as a pilot during the Vietnam War.)  Specifically, as a 20-year-old man, he served as a pilot in the Pacific during World War II.  As detailed in the book Flyboys, on September 2, 1944, while targeting a Japanese radio transmitter on the island of Chichijima, his plane was shot over the Pacific Ocean.  Bush did not abandon his plane, instead continuing to fight until his plane went down.  One source states that his injuries from this combat tragedy, that took the lives of many of his squadron, included “bleeding from a headwound”.

“Why had I been spared and what did God have in store for me?… there’s got to be some kind of destiny and I was being spared for something of Earth,” Bush later said about his trauma in WWII.  For those with disabilities, part of that reason was definitely his signing of the American Disabilities Act on July 26, 1990.  Modeled after the Civil Rights Act of 1964, the ADA aimed for equal opportunity for those with disabilities.  While a list of what impairments constitute a disability is not defined in the Act, a disability is defined as, “a physical or mental impairment that substantially limits one or more major life activities of such individual.”  These limiting impairments include, “functions of the… neurological, brain…”

Following his presidency, President Bush continued to support those with brain injury.  For example, in 1996, President Bush created a PSA for the Pediatric Brain Injury Prevention Campaign.  Prior to the PSA, the Campaign had no association with President Bush.  He agreed to do the PSA simply based on a request submitted through letter.

Recently, President Bush suffered through his own trauma – vascular Parkinsonism.  Thought to be caused by a multitude of mini strokes, vascular Parkinsonism is so named because it shares many of the characteristics of Parkinson’s disease.  (Some dispute this correlation, as Parkinson’s can be helped by medication, but vascular Parkinsonism cannot.)  On Friday, November 30, 2018, President, Vice President, Congressman and CIA Director Bush passed away.  After his funeral, his body will travel to Texas where he will be laid to rest next to his wife of over 70 years, Barbara and his young daughter Robin.  For the disabled, his legacy of the ADA will continue.