For years, doctors worried that antidepressants might worsen brain bleeding after traumatic brain injury. A 2026 study published in Neurology and cataloged in the U.S. National Library of Medicine challenges that fear. Finnish researchers tracked 54,876 brain injury patients over thirteen years and found something unexpected: those taking antidepressants showed no increased risk of death or emergency surgery. “These findings provide reassurance for people who take antidepressants that antidepressant use does not appear to worsen early recovery after traumatic brain injury,” said lead author Dr. Jussi P. Posti of Turku University Hospital in January 2026.

The picture grows more complex when considering blood clots. Multiple studies indexed by the NLM show a modest statistical link between antidepressants and clotting. Researchers, though, suggest this association may reflect depression itself rather than the medication, since these drugs actually thin the blood.

This distinction matters enormously. According to federally funded research tracked by the National Institutes of Health, over half of brain injury patients develop depression within their first year of recovery, and they face eight times the general population’s depression risk. The CDC explicitly recommends screening and treating this depression because untreated cases impair cognitive recovery and triple non-adherence to rehabilitation.

Most critically, NIH-hosted research shows brain injury survivors face nearly twice the suicide risk of others, with depression as the strongest predictor. The government’s message is clear: not treating depression after brain injury can carry serious, documented dangers.